取代的6-氯-2,3,4,5-四氢-7,8-二羟基-1-苯基-1H-3-苯并氮杂卓中强效中枢和肾多巴胺激动剂活性的分离 - Suppr

Separation of potent central and renal dopamine agonist activity in substituted 6-chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepines.

作者信息

Weinstock J, Wilson J W, Ladd D L, Brush C K, Pfeiffer F R, Kuo G Y, Holden K G, Yim N C, Hahn R A, Wardell J R, Tobia A J, Setler P E, Sarau H M, Ridley P T

出版信息

J Med Chem. 1980 Sep;23(9):973-5. doi: 10.1021/jm00183a001.

DOI:10.1021/jm00183a001

PMID:7411552

Abstract

摘要

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Separation of potent central and renal dopamine agonist activity in substituted 6-chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepines.取代的6-氯-2,3,4,5-四氢-7,8-二羟基-1-苯基-1H-3-苯并氮杂卓中强效中枢和肾多巴胺激动剂活性的分离

J Med Chem. 1980 Sep;23(9):973-5. doi: 10.1021/jm00183a001.

Dopaminergic activity of substituted 6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines.取代的6-氯-1-苯基-2,3,4,5-四氢-1H-3-苯并氮杂䓬的多巴胺能活性。

J Med Chem. 1982 Apr;25(4):352-8. doi: 10.1021/jm00346a005.

Synthesis and renal vasodilator activity of some dopamine agonist 1-aryl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diols: halogen and methyl analogues of fenoldopam.某些多巴胺激动剂1-芳基-2,3,4,5-四氢-1H-3-苯并氮杂卓-7,8-二醇的合成及其肾血管舒张活性：非诺多泮的卤素和甲基类似物

J Med Chem. 1986 Nov;29(11):2315-25. doi: 10.1021/jm00161a029.

6-(Phenylthio)-substituted 2,3,4,5-tetrahydro-1H-3-benzazepines, a novel class of dopamine receptor antagonists and neuroleptics.6-（苯硫基）取代的2,3,4,5-四氢-1H-3-苯并氮杂卓类化合物，一类新型多巴胺受体拮抗剂和抗精神病药物。

J Med Chem. 1980 Sep;23(9):975-6. doi: 10.1021/jm00183a002.

Stereoisomeric probes for the D1 dopamine receptor: synthesis and characterization of R-(+) and S-(-) enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its 6-bromo analogue.D1多巴胺受体的立体异构探针：3-烯丙基-7,8-二羟基-1-苯基-2,3,4,5-四氢-1H-3-苯并氮杂卓及其6-溴类似物的R-(+)和S-(-)对映体的合成与表征

J Med Chem. 1992 Apr 17;35(8):1466-71. doi: 10.1021/jm00086a016.

Absolute stereochemistry and dopaminergic activity of enantiomers of 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine.

J Med Chem. 1982 Jun;25(6):697-703. doi: 10.1021/jm00348a017.

A study on the contribution of the 1-phenyl substituent to the molecular electrostatic potentials of some benzazepines in relation to selective dopamine D-1 receptor activity.一项关于1-苯基取代基对某些苯并氮杂䓬类化合物分子静电势的贡献及其与选择性多巴胺D-1受体活性关系的研究。

J Med Chem. 1992 Feb 7;35(3):502-7. doi: 10.1021/jm00081a010.

(+/-)-3-allyl-7-halo-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines as selective high affinity D1 dopamine receptor antagonists: synthesis and structure-activity relationship.

J Med Chem. 1992 Jan;35(1):67-72. doi: 10.1021/jm00079a008.

Renal vascular activity of SK&F 38393 and dopamine in anesthetized dogs.麻醉犬中SK&F 38393和多巴胺的肾血管活性

J Cardiovasc Pharmacol. 1980 Sep-Oct;2(5):583-93. doi: 10.1097/00005344-198009000-00008.

Dopamine agonists related to 3-allyl-6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzaz epi ne-7, 8-diol. 6-Position modifications.与3-烯丙基-6-氯-2,3,4,5-四氢-1-(4-羟基苯基)-1H-3-苯并氮杂卓-7,8-二醇相关的多巴胺激动剂。6-位修饰。

J Med Chem. 1987 Jan;30(1):35-40. doi: 10.1021/jm00384a006.

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Synthesis of Chiral Tetrahydro-3-benzazepine Motifs by Iridium-Catalyzed Asymmetric Hydrogenation of Cyclic Ene-carbamates.手性四氢-3-苯氮杂䓬结构的铱催化不对称氢化环烯酰胺的合成。

Org Lett. 2022 Mar 18;24(10):1969-1973. doi: 10.1021/acs.orglett.2c00362. Epub 2022 Mar 3.

Fenoldopam Mesylate: A Narrative Review of Its Use in Acute Kidney Injury.甲磺酸酚妥拉明：在急性肾损伤中的应用的综述。

Curr Pharm Biotechnol. 2019;20(5):366-375. doi: 10.2174/1389201020666190417124711.

Observational studies of dopamine D1 and D2 agonists in squirrel monkeys.松鼠猴中多巴胺D1和D2激动剂的观察性研究。

Psychopharmacology (Berl). 1994 Sep;116(1):9-18. doi: 10.1007/BF02244865.

Selective peripheral dopamine-1 receptor stimulation with fenoldopam in human essential hypertension.非诺多泮对人原发性高血压患者外周多巴胺-1受体的选择性刺激作用

J Clin Invest. 1984 Dec;74(6):2198-207. doi: 10.1172/JCI111646.

Modulation by fenoldopam (SKF 82526) and bromocriptine of the electrically evoked release of vasopressin from the rat neurohypophysis. Effects of dopamine depletion.非诺多泮（SKF 82526）和溴隐亭对大鼠神经垂体电诱发血管加压素释放的调节作用。多巴胺耗竭的影响。

Naunyn Schmiedebergs Arch Pharmacol. 1986 Apr;332(4):332-7. doi: 10.1007/BF00500083.

Arterial medial necrosis and hemorrhage induced in rats by intravenous infusion of fenoldopam mesylate, a dopaminergic vasodilator.静脉输注多巴胺能血管扩张剂甲磺酸非诺多泮可诱导大鼠发生动脉中层坏死和出血。

Am J Pathol. 1985 Apr;119(1):83-91.

Role of dopaminergic and adrenergic receptors in the pathogenesis of arterial lesions induced by fenoldopam mesylate and dopamine in the rat.多巴胺能和肾上腺素能受体在甲磺酸非诺多泮和多巴胺诱导的大鼠动脉病变发病机制中的作用。

Am J Pathol. 1989 Aug;135(2):339-49.

Lack of autoreceptor mediated regulation of the spontaneous dopamine turnover in the isolated neurointermediate lobe of the rat pituitary gland in vitro.大鼠垂体腺离体神经中间叶中缺乏自受体介导的对自发多巴胺周转的调节。

Naunyn Schmiedebergs Arch Pharmacol. 1990 Mar;341(3):182-5. doi: 10.1007/BF00169728.

Effects of selective D1 and D2 dopamine agonists on cockroach salivary gland acinar cells in vitro.选择性D1和D2多巴胺激动剂对离体蟑螂唾液腺腺泡细胞的影响。

Br J Pharmacol. 1991 Dec;104(4):787-92. doi: 10.1111/j.1476-5381.1991.tb12507.x.

Actions of dopamine and dopaminergic drugs on cloned serotonin receptors expressed in Xenopus oocytes.多巴胺及多巴胺能药物对非洲爪蟾卵母细胞中表达的克隆5-羟色胺受体的作用。

Proc Natl Acad Sci U S A. 1992 May 15;89(10):4708-12. doi: 10.1073/pnas.89.10.4708.

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Separation of potent central and renal dopamine agonist activity in substituted 6-chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepines.

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