Schindler R A
Laryngoscope. 1980 Jun;90(6 Pt 2):1-39.
The present investigation describes the ultrastructure of the human endolymphatic sac in surgical biopsy specimens from 14 patients with acoustic neuroma and Ménière's disease. The intent of the study is to illustrate the normal appearing human endolymphatic sac by transmission electronmicroscopy (TEM) and to detail histopathologic alterations which occur in patients with acoustic neuroma and Ménière's disease. Normal endolymphatic sac histology is elucidated and provides a basis for discussing pathologic changes seen in disease states. The endolymphatic sac undergoes similar histopathologic changes in patients with acoustic neuroma and Ménière's disease. Epithelial degeneration, thickening of the basilar lamina and perisaccular fibrosis appear in both disease processes. The presence of similar pathologic changes in the endolymphatic sac patients with acoustic neuroma and Ménière's disease suggests that the sac degeneration is the result of the disease process and not necessarily its cause.
本研究描述了14例听神经瘤和梅尼埃病患者手术活检标本中人类内淋巴囊的超微结构。该研究的目的是通过透射电子显微镜（TEM）阐明外观正常的人类内淋巴囊，并详细描述听神经瘤和梅尼埃病患者发生的组织病理学改变。正常内淋巴囊组织学得到阐明，为讨论疾病状态下所见的病理变化提供了基础。听神经瘤和梅尼埃病患者的内淋巴囊经历相似的组织病理学变化。上皮变性、基底膜增厚和囊周纤维化在这两种疾病过程中均出现。听神经瘤和梅尼埃病患者的内淋巴囊中存在相似的病理变化，这表明囊变性是疾病过程的结果，而不一定是其病因。
