长期使用甲氧氯普胺治疗会诱导对阿扑吗啡的行为超敏反应，并增强3H-螺哌啶醇与大鼠纹状体的特异性结合。 - Suppr | 超能文献

Chronic treatment with metoclopramide induces behavioral supersensitivity to apomorphine and enhances specific binding of 3H-spiroperidol to rat striata.

作者信息

Lautin A, Wazer D, Stanley M, Rotorsen J, Gershon S

出版信息

Life Sci. 1980 Jul 28;27(4):305-16. doi: 10.1016/0024-3205(80)90198-8.

DOI:10.1016/0024-3205(80)90198-8

Abstract

摘要

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Chronic treatment with metoclopramide induces behavioral supersensitivity to apomorphine and enhances specific binding of 3H-spiroperidol to rat striata.长期使用甲氧氯普胺治疗会诱导对阿扑吗啡的行为超敏反应，并增强3H-螺哌啶醇与大鼠纹状体的特异性结合。

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Effects of chronic haloperidol, thioridazine and zotepine treatment on apomorphine elicited stereotypic behavior and 3H-spiroperidol binding sites in the striatum of the rat.慢性氟哌啶醇、硫利达嗪和佐替平治疗对阿扑吗啡诱发的大鼠纹状体刻板行为及3H-螺哌啶醇结合位点的影响。

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引用本文的文献

1

Metoclopramide: antipsychotic efficacy of a drug lacking potency in receptor models.甲氧氯普胺：一种在受体模型中缺乏效力的药物的抗精神病疗效。

Psychopharmacology (Berl). 1980;71(3):219-25. doi: 10.1007/BF00433055.

2

Regional differences in the induction of behavioral supersensitivity by prolonged treatment with atypical neuroleptics.非典型抗精神病药物长期治疗诱导行为超敏反应的区域差异。

Psychopharmacology (Berl). 1989;98(3):386-91. doi: 10.1007/BF00451692.