Gass J D
Ophthalmology. 1980 Jun;87(6):523-8. doi: 10.1016/s0161-6420(80)35200-7.
One hundred and sixteen patients with suspected malignant melanoma of the choroid and ciliary body were observed for evidence of tumor growth prior to enucleation. All patients were followed for a minimum of five years after tumor detection. The tumor failed to grow in 69 patients, and none developed evidence of metastatic melanoma. The tumor grew in 47 patients, and 35 patients had enucleation. Five patients (4 having enucleation) died of metastatic melanoma. Deaths caused by other primary malignancies (9 patients) and other causes (11 patients) outnumbered those caused by melanomas. The clinical accuracy of predicting growth of small and medium suspected melanomas was approximately 75%. Five patients died because of metastatic melanoma. This study demonstrated no evidence of increased mortality caused by observation of small tumors for evidence of growth prior to enucleation.
116例疑似脉络膜和睫状体恶性黑色素瘤的患者在眼球摘除术前接受观察，以寻找肿瘤生长的证据。所有患者在肿瘤检测后至少随访5年。69例患者的肿瘤未生长，且均未出现转移性黑色素瘤的证据。47例患者的肿瘤生长，其中35例接受了眼球摘除术。5例患者（4例接受了眼球摘除术）死于转移性黑色素瘤。其他原发性恶性肿瘤导致的死亡（9例）和其他原因导致的死亡（11例）超过了黑色素瘤导致的死亡。预测中小型疑似黑色素瘤生长的临床准确率约为75%。5例患者死于转移性黑色素瘤。这项研究没有显示出在眼球摘除术前观察小肿瘤生长证据会导致死亡率增加的迹象。
