Thompson K G, Fraser A J, Harrop B M, Kirk J A
Res Vet Sci. 1980 May;28(3):321-4.
The concentration of selenium (Se) in liver, serum and whole blood, and the activity of glutathione peroxidase (GSH-px) in serum and erythrocytes were monitored for seven months after the administration of Se to Se-deficient calves. There was a rapid increase in Se concentration in liver and serum, followed by an exponential decline with half-lives of 22.1 +/- 0.2 days and 28.3 +/- 2.0 days respectively. Whole blood Se concentration also increased rapidly but declined more slowly than liver or serum Se concentraations. The rise in Se concentration and GSH-px activity in erythrocytes was delayed and both levels remained elevated several months after liver and serum Se concentrations had become marginal or deficient. GSH-px activity in serum increased more rapidly after dosing and declined more rapidly than GSH-px activity in erythrocytes. The results suggest that liver and serum Se concentration and serum GSH-px activity respond to changes in dietary Se intake more rapidly than either whole blood Se or erythrocyte GSH-px activity. Two-monthly administrations of Se, at the current recommended therapeutic dose (0.1 mg Se/kg as sodium selenate) appears to be necessary to maintain adequate Se levels in calves on Se-deficient pasture.
对缺硒犊牛补硒后七个月内，监测其肝脏、血清和全血中的硒（Se）浓度，以及血清和红细胞中的谷胱甘肽过氧化物酶（GSH-px）活性。肝脏和血清中的硒浓度迅速升高，随后呈指数下降，半衰期分别为22.1±0.2天和28.3±2.0天。全血硒浓度也迅速升高，但下降速度比肝脏或血清硒浓度慢。红细胞中硒浓度和GSH-px活性的升高出现延迟，在肝脏和血清硒浓度降至临界或缺乏水平数月后，这两个水平仍保持升高。给药后血清中GSH-px活性升高更快，且比红细胞中GSH-px活性下降更快。结果表明，肝脏和血清硒浓度以及血清GSH-px活性对日粮硒摄入量变化的反应比全血硒或红细胞GSH-px活性更快。对于在缺硒牧场上的犊牛，按当前推荐治疗剂量（0.1 mg硒/千克，以亚硒酸钠形式）每两个月补硒一次，似乎有必要维持足够的硒水平。
