Waleffe A, Kulbertus H E
Acta Cardiol. 1977;32(4):269-82.
Twelve patients with severe ventricular dysrhythmias were treated by one single dose of 250 mg of mexiletine injected intravenously over a 15 min. period. All patients showed some antiarrhythmic response. In 9 cases, the ventricular premature beats were totally or almost totally abolished up to 20 to 100 min. after the end of the infection. In most patients (5/7), there existed a correlation between the plasma concentration of the drug and the antiarrhymic action. However, the drug levels were not different in the good responders as compared to the poor responders or in those who manifested a prolonged antiarrhythmic activity as compared to the others. Side-effect appeared in three cases and consisted of vomiting, tremor, and episodes of sinus arrest.
12例严重室性心律失常患者接受了单次静脉注射250毫克美西律的治疗，注射时间为15分钟。所有患者均表现出一定的抗心律失常反应。9例患者在注射结束后20至100分钟内室性早搏完全或几乎完全消失。在大多数患者（5/7）中，药物血浆浓度与抗心律失常作用之间存在相关性。然而，反应良好者与反应较差者相比，或表现出延长抗心律失常活性者与其他患者相比，药物水平并无差异。3例出现副作用，包括呕吐、震颤和窦性停搏发作。
