Khanna O P, Barbieri E J, McMichael R
Urology. 1978 Dec;12(6):674-81. doi: 10.1016/0090-4295(78)90430-2.
The effects of PGF 2-alpha and PGE2 on the vesicourethral smooth muscle of the rabbit were studied in vitro. PGF2-alpha had potent contractile effects on the bladder body and comparatively less in the bladder base and the proximal urethra. PGE2 contractile effects were two times greater than PGF 2-alpha on the bladder body but minimal or absent on the base and the urethra. The effects of PGF2-alpha and PGE2 seem to be mediated through a prostaglandin receptor as indicated by competitive antagonism of both prostaglandins by N-0164, a synthetic phenyl phosphonate. It also appears that the effects of PGF2-alpha PGE2 may not be mediated through muscarinic, adrenergic, nicotinic, or histaminic receptors or direct smooth-muscle action. The therapeutic implications of PGE2 in the patients with problems of bladder emptying are discussed.
在体外研究了前列腺素F2α（PGF2α）和前列腺素E2（PGE2）对兔膀胱尿道平滑肌的作用。PGF2α对膀胱体有强烈的收缩作用，而对膀胱底部和近端尿道的作用相对较小。PGE2对膀胱体的收缩作用比对PGF2α大两倍，但对膀胱底部和尿道的作用极小或无作用。如合成苯基膦酸酯N-0164对两种前列腺素的竞争性拮抗作用所示，PGF2α和PGE2的作用似乎是通过前列腺素受体介导的。PGF2α和PGE2的作用似乎也不是通过毒蕈碱、肾上腺素能、烟碱或组胺受体或直接平滑肌作用介导的。文中讨论了PGE2在膀胱排空问题患者中的治疗意义。
