[精神分裂症性精神病的基因型特异性]

[Genotypic specificity of schizophrenic psychoses].

作者信息

Shakhmatova-Pavlova I V, Gindilis V M, Rokhlina M L, Kozlova I A

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1980;80(5):719-26.

Abstract

A total of 610 probands with a disease manifestation in childhood, middle and old age and their families were examined by the clinico-genealogical method. The results allowed conclusions that (1) there is an undoubted genetic relationship between schizophrenia of childhood, middle and old age; and that (2) among the closest relatives in families of the probands there is no significant (in comparison to the general population) accumulation of non-schizophrenic pathology. The latter indicates a high genotypic specificity of schizophrenia.

摘要

采用临床系谱法对610名在儿童期、中年期和老年期有疾病表现的先证者及其家族进行了检查。结果表明：（1）儿童期、中年期和老年期的精神分裂症之间存在毋庸置疑的遗传关系；（2）在先证者家族的近亲中，非精神分裂症病理学没有显著（与普通人群相比）聚集。后者表明精神分裂症具有高度的基因型特异性。