吲哚美辛对味蕾组织结构和胆碱酯酶活性的影响。
Effect of indomethacin on the histological structure and cholinesterase activity of taste buds.
作者信息
State F A, Siraffy A, Hamed M S, El-Sherbini G
出版信息
Acta Anat (Basel). 1980;106(1):30-4. doi: 10.1159/000145166.
The present work was undertaken to study the effect of indomethacin on the histological structure and cholinesterase activity of taste buds. 16 adult rabbits were divided into four groups; 2 animals of each group were given a daily oral dose of indomethacin and the other 2 animals were used as controls. The animals were sacrificed at 7, 12, 17 and 30 days, respectively. The areas containing circumvallate and foliate papillae were excised for the study of their histological structure and cholinesterase activity. Administration of indomethacin was followed by a decrease in cholinesterase activity and a shrinkage of the reactive zones of the perigemmal, intragemmal and subgemmal plexuses; the cholinesterase activity eventually disappeared on the 17th day. On the 30th day, it reappeared in the above-mentioned sites. The taste buds did not show any degenerative changes and were similar to those of the controls. The significance of these findings is discussed.
本研究旨在探讨吲哚美辛对味蕾组织结构及胆碱酯酶活性的影响。将16只成年家兔分为四组，每组2只给予每日口服吲哚美辛剂量，另2只作为对照。分别于第7、12、17和30天处死动物。切除包含轮廓乳头和叶状乳头的区域，用于研究其组织结构和胆碱酯酶活性。给予吲哚美辛后，胆碱酯酶活性降低，味蕾周围、味蕾内和味蕾下神经丛的反应区缩小；胆碱酯酶活性最终在第17天消失。在第30天，上述部位的胆碱酯酶活性再次出现。味蕾未显示任何退行性变化，与对照组相似。讨论了这些发现的意义。
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