Raju S, Cibulski A, Hendrix M B
Am Surg. 1980 Sep;46(9):485-93.
True pulmonic and aortic valvular stenoses were produced in dogs by chemical cautery of valve cusps during cardiopulmonary bypass. The intrinsic valve stenoses were confirmed by phonocardiography, gradient measurements, angiography, and pathologic examination. The lesion were similar to clinical valvular stenosis in several respects, including the presence of dystrophic calcification. Unlike the hitherto available models of supravalvular stenosis, the present preparation is amenable to a greater variety and spectrum of experimental studies.
在体外循环期间，通过化学烧灼犬的瓣膜尖来制造真性肺动脉瓣和主动脉瓣狭窄。通过心音图、压力阶差测量、血管造影和病理检查证实了瓣膜的固有狭窄。这些病变在几个方面与临床瓣膜狭窄相似，包括营养不良性钙化的存在。与迄今可用的瓣上狭窄模型不同，目前的制备方法适用于更多种类和范围的实验研究。
