Structure-activity relationships in the effects of phenacemide analogs on serum creatinine and anticonvulsant activity.

The anticonvulsant phenacemide had been shown to produce a marked rise of serum creatinine in humans and experimental animals without significant impairment of renal function. The mechanisms is not yet fully elucidated. A series of aromatic and aliphatic analogs of phenacemide were tested in rabbits under standardized conditions. A number of chemicals-structural requirements for this effect could be recognized within the limited number of compounds available. None of them exceeded the potency of phenacemide. There was no consistent correlation between the effect of serum creatinine and anticonvulsant potency in mice.