Ravaris C L, Robinson D S, Ives J O, Nies A, Bartlett D
Arch Gen Psychiatry. 1980 Sep;37(9):1075-80. doi: 10.1001/archpsyc.1980.01780220113013.
We present the results of a direct comparison of pheneizine sulfate and amitriptyline hydrochloride therapy in 105 depressed patients. We believe this is the first definitive double-blind controlled clinical trial of a monoamine oxidase inhibitor and a tricyclic antidepressant in the outpatient setting. The results show both antidepressants to be effective, with the similarities between the two exceeding the differences. Both drugs had marked antidepressant and antianziety effects. Phenelzine tended to exert a stronger antianxiety action; amitriptyline was more effective in reversing weight loss and improving sleep. The incidence of two side effects, sedation and orthostatic hypotension, was almost identical. Dry mouth was more prevalent with amitriptyline. We discuss the indications for the differential clinical use of both drugs in depressed outpatients.
我们展示了对105名抑郁症患者进行硫酸苯乙肼和盐酸阿米替林治疗直接比较的结果。我们认为这是在门诊环境中对单胺氧化酶抑制剂和三环类抗抑郁药进行的首个权威性双盲对照临床试验。结果表明两种抗抑郁药均有效，两者之间的相似之处超过差异。两种药物都有显著的抗抑郁和抗焦虑作用。苯乙肼倾向于发挥更强的抗焦虑作用；阿米替林在逆转体重减轻和改善睡眠方面更有效。两种副作用，即镇静和体位性低血压的发生率几乎相同。口干在阿米替林治疗中更为普遍。我们讨论了这两种药物在门诊抑郁症患者中差异临床应用的指征。
