Klembovskiĭ A I
Arkh Patol. 1980;42(7):29-39.
Three hundred ten children varying in ages from 2 to 15 years suffering from glomerulopathies (GP) of different etiologies including glomerulonephritis, hereditary nephritis, GP in renal congenital abnormalities of position and quantity were examined using methods of clinical morphology, with determinations of immunological values of T- and B-cell immunity and examinations of kidney biopsies by light, luminescent and electron microscopy (transmissive and scanning). Ten clinico-immuno-morphological variants of glomerular nephropathy were distinguished and characterized. Manifestations of GP were found to depend considerably on the age of the patient the influence of which was superimposed on the effect of etiological factors. GP morphogenesis depends on differences in the level and ratio of activity of immune reactions which parallel the state of glomerular cells and types of changes in its structure. Most specific features of pediatric GP include minimal and proliferative (mesangial) variants in which hypoplasia of glomerular elements and instability of cytomembranes of nephron are frequently found.
对310名年龄在2至15岁之间、患有不同病因肾小球疾病（GP）的儿童进行了检查，这些病因包括肾小球肾炎、遗传性肾炎、肾先天性位置和数量异常中的GP，采用临床形态学方法，测定T细胞和B细胞免疫的免疫学值，并通过光镜、荧光镜和电子显微镜（透射和扫描）对肾活检进行检查。区分并描述了肾小球肾病的10种临床免疫形态学变体。发现GP的表现很大程度上取决于患者的年龄，年龄的影响叠加在病因因素的作用之上。GP的形态发生取决于免疫反应活性水平和比率的差异，这些差异与肾小球细胞状态及其结构变化类型平行。小儿GP最具特征性的表现包括微小病变型和增殖性（系膜）型，其中常发现肾小球成分发育不全和肾单位细胞膜不稳定。
