Korolev V V, Akhmatov V I, Stefanov S B
Arkh Patol. 1980;42(7):58-63.
The time course of quantitative changes in the ultrastructure of capillaries and muscle fibrers was studied by the totality of morphological signs in 33 patients with obliterating endarteritis of the lower extremities. As the disease develops, the area of luminal surface and the volume of basal membrane of the capillaries and mitochondria of muscle fibers increase progressively; the volume and number of micropinocytotic vesicles, the volume of myofibrills and the ratio of myofibrill to the mitochondria volume decrease. In early stages of the disease the size of capillary lumen decreases and subsequently increases along with a decrease in the volume of endothelial cells. An increase in the number of mitochondria in a unit of area of muscle fiber at early stages with subsequent decrease was noted. All the values of observed changes are statistically significant. None of the examined features of the structure can be considered pathognomonic separately, but the totality of the quantitative alterations gives a whole picture of the progressive disease.
通过综合形态学特征，对33例下肢闭塞性动脉内膜炎患者的毛细血管和肌纤维超微结构的定量变化时间进程进行了研究。随着疾病发展，毛细血管腔表面面积、肌纤维基底膜体积和线粒体体积逐渐增加；微吞饮小泡的体积和数量、肌原纤维体积以及肌原纤维与线粒体体积之比降低。在疾病早期，毛细血管腔大小减小，随后随着内皮细胞体积减小而增大。注意到在疾病早期单位面积肌纤维中线粒体数量增加，随后减少。观察到的所有变化值均具有统计学意义。所检查的结构特征单独来看均不能被视为具有病理诊断意义，但定量改变的总体情况呈现出该进行性疾病的全貌。
