Wilson D R, Cusimano M, Honrath U
Can J Physiol Pharmacol. 1980 May;58(5):477-83. doi: 10.1139/y80-080.
The role of the renal nerves in the altered sodium reabsorption which occurs during increased ureteral pressure was studied using clearance techniques in anaesthetized rats undergoing diuresis induced by isotonic saline infusion. In rats with a sham denervated kidney, an ipsilateral increase in ureteral pressure to 20 cm H2O resulted in a marked and significant decrease in sodium and water excretion, increased fractional sodium reabsorption, and increased urine osmolality with no significant change in glomerular filtration rate. A similar significant ipsilateral increase in tubular reabsorption of sodium occurred in rats with chronically denervated kidneys during increased ureteral pressure. The changes in tubular reabsorption were rapidly reversible after return of ureteral pressure to normal. These experiments indicate that enhanced tubular reabsorption of sodium during an ipsilateral increase in ureteral pressure is not mediated by increased renal nerve activity. During the antinatriuresis of increased ureteral pressure there was a decrease in the fractional reabsorption of sodium from the opposite normal kidney. The role of the renal nerves in this compensatory change in function in the opposite kidney was studied in two further groups of animals. The renal response to a contralateral increase in ureteral pressure was similar in denervated and sham-denervated kidneys. The results indicate that altered renal nerve activity, through ipsilateral or contralateral renorenal reflexes, is not responsible for the changes in tubular reabsorption of sodium which occur during increased ureteral pressure induced by partial ureteral obstruction.
采用清除率技术，对静脉输注等渗盐水诱导利尿的麻醉大鼠进行研究，以探讨输尿管压力升高时肾神经在钠重吸收改变中所起的作用。在假去神经支配肾脏的大鼠中，同侧输尿管压力升高至20 cm H₂O会导致钠和水排泄显著减少、钠重吸收分数增加、尿渗透压升高，而肾小球滤过率无显著变化。在输尿管压力升高期间，慢性去神经支配肾脏的大鼠也出现了类似的同侧肾小管钠重吸收显著增加。输尿管压力恢复正常后，肾小管重吸收的变化可迅速逆转。这些实验表明，同侧输尿管压力升高期间肾小管钠重吸收增强并非由肾神经活动增加介导。在输尿管压力升高引起的钠尿减少过程中，对侧正常肾脏的钠重吸收分数降低。在另外两组动物中研究了肾神经在对侧肾脏这种功能代偿性变化中的作用。去神经支配和假去神经支配的肾脏对侧输尿管压力升高的肾脏反应相似。结果表明，通过同侧或对侧肾-肾反射改变的肾神经活动，并非输尿管部分梗阻引起输尿管压力升高时肾小管钠重吸收变化的原因。
