Evans W K, Thompson D M, Simpson W J, Feld R, Phillips M J
Cancer. 1980 Oct 1;46(7):1523-7. doi: 10.1002/1097-0142(19801001)46:7<1523::aid-cncr2820460705>3.0.co;2-#.
Combination chemotherapy consisting of cyclophosphamide, vincristine, prednisone, and procarbazine (COPP) was administered to 5 patients with invasive lymphoepithelial thymoma. Objective evidence of tumor regression was seen in 4 patients. Given prior to preoperative radiation therapy, COPP produced partial remissions in 2 patients, making possible smaller radiation treatment fields. Two patients with pleural involvement when first seen, achieved tumor regression when COPP was given prior to radical radiation therapy. One of these patients remains disease-free at 34 months; the other succumbed to pneumonitis. One patient, presenting with pleural metastasis three years after undergoing incomplete resection of thymoma, failed to respond to treatment. Combination chemotherapy with COPP can produce objective regression of invasive lymphoepithelial thymomas which may be useful in the preoperative management of selected cases, as well as in the management of unresectable or metastatic disease.
对5例侵袭性淋巴上皮性胸腺瘤患者给予由环磷酰胺、长春新碱、泼尼松和丙卡巴肼组成的联合化疗（COPP）。4例患者出现肿瘤消退的客观证据。在术前放疗前给予COPP，2例患者实现部分缓解，使较小的放疗野成为可能。首次就诊时有胸膜受累的2例患者，在根治性放疗前给予COPP时实现了肿瘤消退。其中1例患者在34个月时仍无疾病；另1例死于肺炎。1例患者在胸腺瘤不完全切除三年后出现胸膜转移，对治疗无反应。COPP联合化疗可使侵袭性淋巴上皮性胸腺瘤出现客观消退，这在部分病例的术前管理以及不可切除或转移性疾病的管理中可能有用。
