Gerretsen G, Kremer J, Bleumink E, Nater J P, de Gast G C, The T H
Contraception. 1980 Jul;22(1):25-9. doi: 10.1016/0010-7824(80)90114-6.
To investigate the influence of sex-steroids on the in vitro correlate of cell-mediated immunity (CMI), blood samples from 49 women on hormonal contraceptives were tested on the lymphocyte response to the mitogens phytohemagglutinin (PHA) and concanavalin A (Con-A). Sixteen women were taking oral contraceptives of combined oestrogen/progestogen of the same brand (low oestrogenic and middle range progestogenic activity); 15 had received intramuscular injections of medroxyprogesterone acetate and 18 women were using a sequential pill. The results were compared with those of 18 women not taking contraceptive steroids and matched for age. No significant changes were observed between the different groups. Considering the previously found alterations in dinitrochlorobenzene (DNCB) skin test reactivity by sex steroids, it is hypothesized that sex-steroids have little or no influence on the central proliferative phase of the immune response, but have a profound effect on the efferent phase.
为研究性类固醇对细胞介导免疫（CMI）体外相关指标的影响，对49名服用激素避孕药的女性的血样进行检测，观察淋巴细胞对丝裂原植物血凝素（PHA）和刀豆球蛋白A（Con-A）的反应。16名女性服用同一品牌的雌激素/孕激素复方口服避孕药（低雌激素活性和中效孕激素活性）；15名女性接受了醋酸甲羟孕酮的肌肉注射，18名女性使用序贯避孕药。将结果与18名未服用避孕类固醇且年龄匹配的女性的结果进行比较。不同组之间未观察到显著变化。鉴于先前发现性类固醇会改变二硝基氯苯（DNCB）皮肤试验反应性，推测性类固醇对免疫反应的中枢增殖阶段影响很小或没有影响，但对传出阶段有深远影响。
