高血压大鼠静脉注射3H-去甲肾上腺素后尿中氚的排泄情况。

Urinary tritium excretion following intravenous 3H-norepinephrine administration in hypertensive rats.

作者信息

Gitlow S, Wong B, Dziedzic L, Dziedzic S

出版信息

Clin Exp Hypertens (1978). 1980 Feb;2(2):169-82. doi: 10.3109/10641968009046418.

DOI:10.3109/10641968009046418

Abstract

Spontaneously hypertensive rats (SHR), salt-resistant (SRR), salt-sensitive (SSR), and Sprague-Dawley DOC-salt nephrectomized rats were tested by evaluation of tritiated norepinephrine uptake and blood pressure with diets containing various amounts of sodium. Only Sprague-Dawley rats who had been both nephrectomized and given DOC on a high salt diet (8%) illustrated the elevated tritium excretion similar to that observed in human subjects with essential hypertension.

摘要

通过评估含不同钠含量饮食条件下的氚标记去甲肾上腺素摄取和血压，对自发性高血压大鼠（SHR）、盐抵抗大鼠（SRR）、盐敏感大鼠（SSR）以及Sprague-Dawley去氧皮质酮盐肾切除大鼠进行了测试。只有接受肾切除并给予高盐饮食（8%）去氧皮质酮的Sprague-Dawley大鼠，其氚排泄量升高，类似于在原发性高血压人类受试者中观察到的情况。