Dunwiddie T V
Epilepsia. 1980 Oct;21(5):541-8. doi: 10.1111/j.1528-1157.1980.tb04305.x.
The role of adenosine in regulating epileptiform discharge was studied in the in vitro hippocampal slice preparation. Exogenously applied adenosine appeared to have anticonvulsant properties (EC50 approximately 10 microM), in that it slowed or suppressed spontaneous interictal discharges. In addition, the release of adenosine (or related adenine nucleotides) from the slice preparation appeared to exert a tonic inhibitory influence on these types of discharges. This provides further evidence supporting a role for adenosine as an endogenous regulator of the excitability of the central nervous system, particularly in convulsive states.
在体外海马脑片制备中研究了腺苷在调节癫痫样放电中的作用。外源性应用的腺苷似乎具有抗惊厥特性（半数有效浓度约为10微摩尔），因为它减缓或抑制了自发性发作间期放电。此外，从脑片制备中释放的腺苷（或相关腺嘌呤核苷酸）似乎对这些类型的放电发挥了强直性抑制作用。这提供了进一步的证据，支持腺苷作为中枢神经系统兴奋性的内源性调节剂的作用，特别是在惊厥状态下。
