Rapid development of acoustic trauma-induced audiogenic seizure risk in 3 strains of seizure-resistant mice.

Audiogenic seizure risk can be induced in genetically seizure resistant mice by exposure to an intense noise a few days prior to testing for seizure. This experiment demonstrates that the priming induced seizure risk can develop within 6-16 h after priming. It was argued that this finding suggested an alternative hypothesis of priming involving peripheral auditory mechanisms.