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普罗帕酮对犬冠状动脉血管平滑肌中TEA诱导的动作电位的影响。

Effects of propafenone on TEA-induced action potentials in vascular smooth muscle of canine coronary arteries.

作者信息

Harder D R, Belardinelli L

出版信息

Experientia. 1980 Sep 15;36(9):1082-3. doi: 10.1007/BF01965982.

DOI:10.1007/BF01965982
PMID:7418845
Abstract

The Ca++-dependent, TEA-induced action potential is blocked by propafenone in a dose-dependent manner. Such results suggests that in coronary arterial smooth muscle one mechanism of action of propafenone is to inhibit Ca++ inward current.

摘要

依赖钙离子的、四乙铵诱导的动作电位被普罗帕酮以剂量依赖的方式阻断。这些结果表明，在冠状动脉平滑肌中，普罗帕酮的一种作用机制是抑制钙离子内流。

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引用本文的文献

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Functional and metabolic effects of propafenone in the rat heart-lung preparation.普罗帕酮对大鼠心肺标本的功能和代谢影响。
J Anesth. 1991 Oct;5(4):392-5. doi: 10.1007/s0054010050392.
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Propafenone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in the treatment of arrhythmias.普罗帕酮。对其药效学和药代动力学特性以及在心律失常治疗中的治疗用途的综述。
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Clinical pharmacokinetics of propafenone.

本文引用的文献

1
[Pharmacology of 2'-[2-hydroxy-3-(propylamino)-propoxy]-3-phenylpropiophenone (Propafenone, SA 79)-hydrochloride].2'-[2-羟基-3-(丙氨基)-丙氧基]-3-苯基苯丙酮（普罗帕酮，SA 79）盐酸盐的药理学
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2
Cardiac glycoside stimulation of inward Ca++ current in vascular smooth muscle of canine coronary artery.强心苷对犬冠状动脉血管平滑肌内向Ca++电流的刺激作用。
J Pharmacol Exp Ther. 1979 Apr;209(1):62-6.
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[The effect of some antiarrhythmic drugs on systolic time intervals in normal subjects (author's transl)].
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Effects of propafenone on 45Ca movements and contractile responses in vascular smooth muscle.普罗帕酮对血管平滑肌中45Ca转运及收缩反应的影响。
Br J Pharmacol. 1991 Jun;103(2):1453-7. doi: 10.1111/j.1476-5381.1991.tb09810.x.
某些抗心律失常药物对正常受试者收缩期时间间期的影响（作者译）
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4
Differential effects of adenosine and nitroglycerin on the action potentials of large and small coronary arteries.腺苷和硝酸甘油对大、小冠状动脉动作电位的不同影响。
Circ Res. 1979 Feb;44(2):176-82. doi: 10.1161/01.res.44.2.176.
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[Indications and risks of anti-arrhythmia treatment with propafenone (author's transl)].
Dtsch Med Wochenschr. 1978 Aug 11;103(32):1261-5. doi: 10.1055/s-0028-1129243.