环己酰亚胺和四氯化碳对艾氏腹水癌荷瘤小鼠的影响。
The effect of cycloheximide and carbon tetrachloride in Ehrlich ascites tumour-bearing mice.
作者信息
Parry E W
出版信息
Gan. 1980 Jun;71(3):275-9.
PMID:7418971
Abstract
Treatment with cycloheximide and a hepatotoxic dose of CCl4 (well tolerated in normal animals) is acutely toxic in animals bearing the Ehrlich ascites tumour. Reduction in tumour load 4 hr after the administration of cycloheximide and CCl4 is life-saving: treatment with a hepatotoxic dose of CCl4 30 hr before challenge with cycloheximide and CCl4 also nullifies that otherwise life-threatening treatment.
摘要
用环己酰亚胺和肝毒性剂量的四氯化碳（正常动物可良好耐受）对携带艾氏腹水瘤的动物进行治疗具有急性毒性。给予环己酰亚胺和四氯化碳4小时后肿瘤负荷降低可挽救生命：在给予环己酰亚胺和四氯化碳之前30小时用肝毒性剂量的四氯化碳进行治疗也可消除原本危及生命的治疗效果。
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