Langhans P
Fortschr Med. 1980 Aug 21;98(30-31):1173-7.
Carcinoma in the operated stomach, a special form of gastric carcinoma, is seen as a late complication of gastric surgery performed in the carcinoma-free stomach. In the presented experimental series a considerable number of carcinomas were observed, for the first time, in rats after gastric sugery without additional application of a carcinogen. The rate of malignancies arising in the operated stomach correlates closely with mode and intensity of the duodenogastric reflux provoked by different surgical procedures, whereby the important role of duodenogastric reflux in the origin and growth of operation sequel carcinoma is established beyond doubt. Observing the coutious reservations needed for transferring experimental results to human conditions, this study may exemplify the value of reflux-preventing techniques in surgical management of gastric diseases. Patients who have undergone an operation have an increased risk of developing carcinoma, and therefore consequent and regular follow-up examinations are necessary. Introduction of surgical prophylaxis and careful postoperative surveillance are the only effective methods for the prevention of operation sequel carcinoma in the stomach.
残胃癌是胃癌的一种特殊形式,被视为在无癌胃中进行胃手术后的晚期并发症。在本实验系列中,首次在未额外施加致癌物的大鼠胃手术后观察到相当数量的癌。残胃中发生恶性肿瘤的比率与不同手术操作引发的十二指肠胃反流的方式和强度密切相关,由此十二指肠胃反流在手术后继发性癌的发生和发展中的重要作用已毋庸置疑。鉴于将实验结果应用于人类情况时需谨慎保留意见,本研究可例证反流预防技术在胃部疾病手术治疗中的价值。接受过手术的患者发生癌的风险增加,因此进行后续定期随访检查是必要的。引入手术预防措施和仔细的术后监测是预防胃手术后继发性癌的唯一有效方法。