Reduction of intraocular pressure in glaucomatous dogs by a new cholinergic drug.

N-Demethylated carbachol (DMC) was synthesized and analyzed for its ocular effects. DMC has been found to penetrate ocular tissue effectively. It has been shown to be free of acute toxic properties in rabbits and dogs at therapeutic doses and has been demonstrated to lower intraocular pressure of glaucomatous beagles without causing intense miosis. The effects of DMC and pilocarpine on outflow facility were compared in normal dogs. At the dose used in these experiments, both drugs affected outflow facility to a similar extent. It is concluded that DMC could be a potentially useful ocular hypotensive agent.