Gwin R M, Gelatt K N, Gum G G, Peiffer R L, Williams L W
Invest Ophthalmol Vis Sci. 1977 Dec;16(12):1143-8.
Topical 1, 2, and 4 percent pilocarpine were evaluated in the normotensive and glaucomatous beagles, comparing intraocular pressure (IOP), pupillary size, and time. In normotensive beagles pilocarpine produced maximal decreases of 25 percent (5.5 mm. Hg) at 1 percent concentration; 34 percent (7.26 mm. Hg) at 2 percent concentration; and 25 percent (6.9 mm. Hg) at 4 percent concentration. The maximum reductions in IOP after pilocarpine instillation in the glaucomatous beagle were 30 percent (9.1 mm. Hg) at 1 percent concentration; 44 percent (14.92 mm. Hg) at 2 percent concentration; and 31 percent (10.89 mm. Hg) at 4 percent concentration. The glaucomatous beagles responded with a greater reduction of IOP than did the normotensive beagles.
对血压正常和患有青光眼的比格犬评估了局部使用1%、2%和4%毛果芸香碱的情况，比较了眼内压（IOP）、瞳孔大小和时间。在血压正常的比格犬中，毛果芸香碱在1%浓度时使眼内压最大降低25%（5.5毫米汞柱）；在2%浓度时降低34%（7.26毫米汞柱）；在4%浓度时降低25%（6.9毫米汞柱）。在患有青光眼的比格犬中，滴入毛果芸香碱后眼内压的最大降低幅度在1%浓度时为30%（9.1毫米汞柱）；在2%浓度时为44%（14.92毫米汞柱）；在4%浓度时为31%（10.89毫米汞柱）。患有青光眼的比格犬比血压正常的比格犬对眼内压的降低反应更大。
