K - 582，一种新型肽类抗生素。一、

K-582, a new peptide antibiotic. I.

作者信息

Kondo S, Meguriya N, Mogi H, Aota T, Miura K, Fujii T, Hayashi I, Makino K, Yamamoto M, Nakajima N

出版信息

J Antibiot (Tokyo). 1980 Jun;33(6):533-42. doi: 10.7164/antibiotics.33.533.

DOI:10.7164/antibiotics.33.533

PMID:7419467

Abstract

A new basic peptide antibiotic designated as K-582 was isolated, purified and characterized. When K-582 was applied to a column of Al2O3 or Biol-Gel P-2 or CM Sephadex, two major peaks which were named Fraction I (K-582 A) and Fraction II (K-582 B) were obtained. The nitrogen content, the behavior in color reaction, the absorption bands of amide linkages in the infrared absorption spectrum, 1H NMR spectrum and C-13 NMR spectrum indicated the peptide nature of K-582 A and K-582 B. K-582 was effective against yeasts, but inactive against other Gram-positive bacteria, Gram-negative bacteria and Mycobacterium. The toxicity was low in mice.

摘要

一种名为K - 582的新型碱性肽抗生素被分离、纯化并进行了特性鉴定。当K - 582应用于氧化铝柱、生物凝胶P - 2柱或CM - 葡聚糖凝胶柱时，得到了两个主要峰，分别命名为组分I（K - 582 A）和组分II（K - 582 B）。氮含量、显色反应表现、红外吸收光谱中酰胺键的吸收带、1H核磁共振谱和碳-13核磁共振谱表明K - 582 A和K - 582 B具有肽的性质。K - 582对酵母有效，但对其他革兰氏阳性菌、革兰氏阴性菌和分枝杆菌无活性。其对小鼠的毒性较低。