Harjola P, Meurala H, Frick M H
J Cardiovasc Surg (Torino). 1980 Jul-Aug;21(4):451-4.
A series of 400 consecutive patients subjected to reconstructive arterial surgery were randomly allocated into four equal groups in order to study the effect of dipyridamole and acetylsalicylic acid (ASA) in the prevention of deep venous thrombosis and pulmonary embolism. There were 11 drop-outs. In the dipyridamole-ASA group there were no thrombotic complications while in the control group without antithrombotic therapy five cases of deep venous thrombosis and two cases of fatal pulmonary embolism were encountered (p < 0.05). In the groups receiving either dipyridamole or ASA alone two and four cases of deep venous thrombosis, respectively, were found. It is concluded that treatment with dipyridamole and ASA combined is useful in preventing postoperative thrombotic complication after peripheral vascular reconstructive surgery.
为研究双嘧达莫和乙酰水杨酸（ASA）预防深静脉血栓形成和肺栓塞的效果，将400例连续接受动脉重建手术的患者随机分为四组，每组人数相等。有11例退出研究。双嘧达莫 - ASA组未发生血栓形成并发症，而在未接受抗血栓治疗的对照组中，有5例发生深静脉血栓形成，2例发生致命性肺栓塞（p < 0.05）。在单独接受双嘧达莫或ASA治疗的组中，分别发现2例和4例深静脉血栓形成。结论是，双嘧达莫和ASA联合治疗对预防周围血管重建手术后的血栓形成并发症有效。
