他莫昔芬可抑制促性腺激素诱导的正常男性体内17α-羟孕酮的蓄积。

Tamoxifen suppresses gonadotropin-induced 17 alpha-hydroxyprogesterone accumulation in normal men.

作者信息

Smals A G, Pieters G F, Drayer J I, Boers G H, Benraad T J, Kloppenborg P W

出版信息

J Clin Endocrinol Metab. 1980 Nov;51(5):1026-9. doi: 10.1210/jcem-51-5-1026.

PMID:7419679

Abstract

Intramuscular administration of 1500 IU hCG daily for 3 days induced a transient accumulation of 17 alpha-hydroxyprogesterone (17 OHP) relative to testosterone (T) in normal men, reaching its maximum 24 h after the first injection (17 OHP to T ratio, 1.7 +/- 0.3 times baseline; P < 0.01). Simultaneous administration of hCG and the estrogen antagonist tamoxifen (20 mg twice daily) almost completely abolished the hCG-induced steroidogenic block localized between 17 OHP and T (17 OHP to T ratio at 24 h, 1.1 +/- 0.1 times baseline; P < 0.01 vs. hCG alone). These data indirectly suggest that, in man, the hCG-induced steroidogenic lesion might be mediated through its estrogen-stimulating effect.

摘要

正常男性连续3天每天肌肉注射1500国际单位人绒毛膜促性腺激素（hCG），相对于睾酮（T），会引起17α-羟孕酮（17 OHP）短暂蓄积，首次注射后24小时达到峰值（17 OHP与T的比值为基线的1.7±0.3倍；P<0.01）。同时给予hCG和雌激素拮抗剂他莫昔芬（每日2次，每次20毫克）几乎完全消除了hCG诱导的位于17 OHP和T之间的类固醇生成阻滞（24小时时17 OHP与T的比值为基线的1.1±0.1倍；与单独使用hCG相比，P<0.01）。这些数据间接表明，在男性中，hCG诱导的类固醇生成损伤可能是通过其雌激素刺激作用介导的。