Ahrens F A, Dyer D C, Lloyd W E
J Toxicol Environ Health. 1980 Jul;6(4):835-42. doi: 10.1080/15287398009529901.
Mirex kinetics were determined in chickens after a single dose of 30 mg/kg iv or 300 mg/kg orally. The decline in blood concentrations was biphasic and suggested uptake of mirex by "fast" and "slow" tissue compartments, with the greatest accumulation in fat and skin 2 wk after administration. Less than 1% of the dose was excreted in 2 wk. Mirex depletion rates in skin and fat were determined in growing chicks fed 1 or 10 ppm mirex in the diet for 1 wk. Calculated disappearance half-times for mirex were 24.8 in skin and 31.5 d in fat. The decrease in tissue concentrations was attributed to dilution in tissue mass accompanying the rapid growth rate rather than to excretion of mirex. The results do not indicate that avian species eliminate mirex more efficently than mammals.
给鸡静脉注射30毫克/千克或口服300毫克/千克单剂量灭蚁灵后，测定了其动力学。血液浓度的下降呈双相性，表明灭蚁灵被“快速”和“缓慢”组织隔室摄取，给药后2周在脂肪和皮肤中的积累量最大。2周内排出的剂量不到1%。在以含1或10 ppm灭蚁灵的饲料喂养1周的生长小鸡中，测定了皮肤和脂肪中灭蚁灵的消耗率。计算得出灭蚁灵在皮肤中的消失半衰期为24.8天，在脂肪中为31.5天。组织浓度的降低归因于伴随快速生长率的组织质量稀释，而非灭蚁灵的排泄。结果并未表明鸟类消除灭蚁灵的效率高于哺乳动物。
