Fusaro R M, Johnson J A
JAMA. 1980 Sep 26;244(13):1456-9.
Hereditary polymorphic light eruption (HPLE) occurs in Indians of North and South America. Affected persons are sensitive to long ultraviolet radiation and therefore receive no substantial benefit from conventional sunscreens. We have treated 46 patients with HPLE at the Red Lake Reservation, Minn, with topically administered dihydroxyacetone and lawsone, orally given beta carotene, or both. Oral beta carotene afforded adequate photoprotection to 33 patients, and four additional patients were protected with the combined use of oral and topical agents. Epidemiologic studies support our proposals that HPLE is a causative factor in streptococcal pyoderma in the American Indian and may be associated with epidemics of streptococcal glomerulonephritis.
遗传性多形性日光疹（HPLE）发生在北美洲和南美洲的印第安人当中。患者对长波紫外线敏感，因此常规防晒霜对他们没有太大效果。我们在明尼苏达州的红湖保留地，用局部涂抹二羟基丙酮和指甲花醌、口服β-胡萝卜素或两者并用的方法，治疗了46例HPLE患者。口服β-胡萝卜素为33例患者提供了足够的光保护，另有4例患者通过口服和局部用药联合使用得到了保护。流行病学研究支持我们的观点，即HPLE是美洲印第安人链球菌脓皮病的一个致病因素，并且可能与链球菌性肾小球肾炎的流行有关。
