Hirose K, Tsuchida H, Osterby R, Gundersen H J
Lab Invest. 1980 Nov;43(5):434-7.
The direct relationship between glomerular filtration surface and glomerulaf filtration rate was studied in a group of eight short term, young diabetics exhibiting a 50 per cent elevated glomerular filtration rate with a 2-fold variation within the group. A close correlation was obtained between glomerular filtration surface and glomerular filtration rate, r = 0.8. This supports the idea that the increase in glomerular capillary surface may be a main factor in diabetic kidney hyperfunction. The possible long term implications of the functional and morphologic abnormalities are discussed.
在一组八名短期年轻糖尿病患者中研究了肾小球滤过面积与肾小球滤过率之间的直接关系，这些患者的肾小球滤过率升高了50%，且组内存在2倍的差异。肾小球滤过面积与肾小球滤过率之间获得了密切的相关性，r = 0.8。这支持了肾小球毛细血管表面积增加可能是糖尿病肾高功能的主要因素这一观点。讨论了功能和形态异常可能的长期影响。
