Adrenoleukodystrophy: white matter disease with adrenal changes in 33-year-old man.

Patients with changes such as those that occur in relatively diffuse disorders of higher nervous function constitute a major diagnostic problem. We are presenting a patient with dysphasia, incoordination, difficulty concentrating, and weight loss with underlying organic changes. This 33-year-old patient had adrenoleukodystrophy (ALD), which is a sex-linked recessive disorder involving the adrenal glands with central nervous system demyelination. ALD usually manifests itself during childhood.