Späti B, Jungi W F, Mayr A C, Hammer B, Senn H J
Schweiz Med Wochenschr. 1980 Jul 8;110(27-28):1076-8.
28 patients with advanced adenocarcinomas were treated with combinations of 5-fluorouracil and mitomycin-C (FM, 21 patients) or of 5-fluorouracil, adriamycin and mitomycin-C (FAM, 7 patients). 5 patients responded, 3 showing an objective response of more than 50% lasting 3-5 months. Toxicity was primarily hematologic, chiefly comprising severe thrombopenias. The results indicate that with these combinations a limited palliative effect can be achieved in only a few patients.
28例晚期腺癌患者接受了5-氟尿嘧啶与丝裂霉素-C联合治疗（FM方案，21例患者）或5-氟尿嘧啶、阿霉素与丝裂霉素-C联合治疗（FAM方案，7例患者）。5例患者有反应，3例出现超过50%的客观反应，持续3 - 5个月。毒性主要为血液学毒性，主要包括严重血小板减少症。结果表明，使用这些联合方案仅能在少数患者中取得有限的姑息治疗效果。
