Rieder H, Lüthy R, Bhend H, Rüttimann S, Münch R, Siegenthaler W
Schweiz Med Wochenschr. 1980 Aug 30;110(35):1273-7.
145 consecutive patients scheduled for a cardiac catheterization were enrolled in a prospective double-blind randomized study to determine the incidence of bacteremia during and following catheterization and the usefulness of antibiotic prophylaxis with cefazolin versus placebo during this procedure. Four blood cultures were taken from each patient to evaluate the incidence of bacteremia vs. contamination. 15 of 296 (5.07%) and 11 of 284 (3.8%) cultures yielded bacteria in the placebo group (74 patients) and in the cefazolin-group (71 patients) respectively. Statistical analysis revealed no significant difference between the groups. These results, together with the spectrum of the organisms isolated and the clinical and laboratory findings, suggest that the isolation of bacteria was due rather to contamination than the result of bacteremia. It is concluded that antibiotic prophylaxis in patients undergoing cardiac catheterization is unnecessary and not indicated.
145例计划接受心导管插入术的连续患者参与了一项前瞻性双盲随机研究，以确定导管插入术期间及术后菌血症的发生率，以及在此过程中使用头孢唑林与安慰剂进行抗生素预防的有效性。从每位患者采集四份血培养样本，以评估菌血症与污染的发生率。安慰剂组（74例患者）的296份培养样本中有15份（5.07%）培养出细菌，头孢唑林组（71例患者）的284份培养样本中有11份（3.8%）培养出细菌。统计分析显示两组之间无显著差异。这些结果，连同分离出的生物体种类以及临床和实验室检查结果表明，细菌的分离更可能是由于污染而非菌血症的结果。得出的结论是，接受心导管插入术的患者无需进行抗生素预防，也无此必要。
