Seifert B, Liedtke M P, Kempf H J, Richter H, Alexander H, Herter U
Acta Biol Med Ger. 1978;37(5-6):949-50.
In 100 patients a total of 171 PG determinations in the menstrual blood was performed under standardized conditions. The primary PGE1 and PGF2alpha were determined by RIA. The evaluation of the analysis of the sexual hormones resulted in a group with a biphasic cycle without dysmenorrhoea and a group with a biphasic cycle with dysmenorrhoea. Highly significant differences (p less than 0.01) were found in the PGF2alpha concentration in menstrual blood between a group of healthy women and one of patients with dysmenorrhoea. In dysmenorrhoea the ratio of the PGs investigated is shifted in favour of PGF2alpha. Indomethacin can decrease the PGF2alpha levels in dysmenorrhoea up to 15% (p less than 0.01). All treated patients reported that their conditions had improved. Five out of seven women were completely without any complaints.
在100名患者中，在标准化条件下对月经血进行了总共171次前列腺素（PG）测定。主要的前列腺素E1（PGE1）和前列腺素F2α（PGF2α）通过放射免疫分析（RIA）测定。对性激素分析的评估产生了一个无痛经的双相周期组和一个有痛经的双相周期组。在一组健康女性和一组痛经患者的月经血中，PGF2α浓度存在高度显著差异（p小于0.01）。在痛经中，所研究的前列腺素比例偏向于PGF2α。吲哚美辛可使痛经患者的PGF2α水平降低多达15%（p小于0.01）。所有接受治疗的患者均报告病情有所改善。七名女性中有五名完全没有任何不适。
