Intravaginal prostaglandin E2 for cervical ripening and induction of labour. A comparison of gel and tablets.

Prostaglandin E2 (PGE2) 4,5 mg in the form of either 0,5 mg oral tablets or tylose gel, was inserted intravaginally to induce labour in 11 pairs of patients with an unripe cervix. Labour commenced spontaneously in 68% of the patients and there was no difference in efficacy or complications between the tablets and the gel. PGE2 in tylose gel was originally introduced as the optimal preparation, but is not readily available. PGE2 oral tablets, inserted vaginally, although not ideal, are available and are as effective. The use of intravaginal PGE2 for induction of labour is a significant advance in obstetric practice.