[Effect of hydrochlorothiazide on acid secretion and potassium and sodium in the human gastric mucosa].

Hydrochlorotiazide induced changes of gastric acid secretion, Sodium (Na) and potassium (K) of human gastric mucosa". In ten patients with elevated acid secretion we determined maximal acid secretion after histamine stimulation, Na and K in serum and in fundic mucosa obtained by peroral gastric biopsy. These experiments were performed before and after the oral administration of hydrochlorotiazide (200 mg/day) during seven days. After diuretic treatment we observed a significant decrease of Na (P less than 0.01) and K (p less than 0.05) in gastric mucosa. Both ions also decreased significantly in plasma (p less than 0.01). In gastric juice the decrease was significant for volume and peak acid output (p less than 0.01) and for total acidity (p less than 0.05). The significance of these findings is discussed.