大鼠吸入1,1,2-三氯-1,2,2-三氟乙烷的剂量依赖性神经化学效应。

Dose-dependent neurochemical effects of 1,1,2-trichloro-1,2,2-trifluoroethane inhalation exposure in rats.

作者信息

Savolainen H, Pfäffli P

出版信息

Toxicol Lett. 1980 Jun;6(1):43-9. doi: 10.1016/0378-4274(80)90101-0.

Abstract

Male Wistar rats were exposed to 200, 1000 or 2000 ppm of 1,1,2-trichloro-1,2,2-trifluoroethane vapour for 2 weeks, 5 day/week, 6 h daily and showed a dose-dependent accumulation of the compound in perirenal fat and brain. In the first week increased NADPH-diaphorase activity was observed and there was decreased cerebral glutathione at the highest dose. During the second week these effects disappeared while RNA tended to increase, and glutathione peroxidase activity to decrease at the highest dose. After a withdrawal period of 7 days, no fluorohydrocarbon was detected and the neurochemical effects had disappeared except that brain RNA at the highest exposure was below the control range.

摘要

将雄性Wistar大鼠暴露于浓度为200、1000或2000 ppm的1,1,2-三氯-1,2,2-三氟乙烷蒸气中，每周5天，每天6小时，持续2周，结果显示该化合物在肾周脂肪和大脑中呈剂量依赖性蓄积。在第一周，观察到NADPH-黄递酶活性增加，且在最高剂量时脑内谷胱甘肽减少。在第二周，这些效应消失，而RNA趋于增加，且在最高剂量时谷胱甘肽过氧化物酶活性降低。经过7天的撤药期后，未检测到氟代烃，除最高暴露组的脑RNA低于对照范围外，神经化学效应均已消失。