Blohm M, Braun H, Kaschny P, Schill W, Jastorff B, Diehl H
Ecotoxicol Environ Saf. 1985 Dec;10(3):295-301. doi: 10.1016/0147-6513(85)90076-4.
The metabolism of the xenobiotics 1,1,1-trichloroethane (TCE) or 1,1,2-trichloro-1,2,2-trifluoroethane and endogeneous substrates may be changed under physiological stress situations. We studied long-term effects on rats exposed to TCE, noise pollution, and their combination. The experiments were performed in a special set-up where four parallel groups of rats were simultaneously exposed to defined conditions the chemical vapor; the noise pollution of 90 dB; their combination; and a control group without any exposure. The vapor of TCE was applied at a concentration of 200 ppm/8 hr or of 2000 ppm/12 hr for 84 days each. The experiments were performed with TCE from two different commercial sources. One of those TCE preparations caused effects at the high dosage level in terms of enhanced levels of the relation of liver to body weight; liver microsomal protein content; liver microsomal monooxygenase activity; and 3,4-dihydroxyphenylglycol excretion in urine. Eight other physiological and biochemical parameters were not changed.
在生理应激情况下，异生物1,1,1 - 三氯乙烷（TCE）或1,1,2 - 三氯 - 1,2,2 - 三氟乙烷以及内源性底物的代谢可能会发生变化。我们研究了长期暴露于TCE、噪声污染及其组合对大鼠的影响。实验在一种特殊装置中进行，四组平行的大鼠同时暴露于特定条件下：化学蒸汽；90分贝的噪声污染；它们的组合；以及未暴露于任何因素的对照组。TCE蒸汽以200 ppm/8小时或2000 ppm/12小时的浓度分别施加84天。实验使用了来自两种不同商业来源的TCE。其中一种TCE制剂在高剂量水平下导致肝脏与体重之比、肝脏微粒体蛋白含量、肝脏微粒体单加氧酶活性以及尿中3,4 - 二羟基苯乙二醇排泄量增加。其他八个生理和生化参数未发生变化。
