Involvement of glucocorticoids in the stimulation of rat kidney phosphoenolpyruvate carboxykinase activity after liver intoxication by carbon tetrachloride.

The enhancement of rat kidney cortex phosphoenolpyruvate carboxykinase activity during acute liver intoxication by carbon tetrachloride (CCl4) did not appear to be related to metabolic acidosis. Blood glucocorticoids were higher in CCl4-treated animals than in controls. Adrenalectomy fully counteracted the stimulation of renal phosphoenolpyruvate carboxykinase activity and gluconeogenic capacity brought about by CCl4 administration. It is concluded that glucocorticoids are involved in the renal response to acute liver intoxication by CCl4.