Budihna M, Skrk J, Smid L, Furlan L
Strahlentherapie. 1980 Jun;156(6):402-8.
Fifty-two patients who were treated for laryngeal carcinoma stage I and II by either continuous or split-course irradiation were analysed. The 5-year cure by irradiation was the same in both groups. An isoeffect line was drawn for cured tumours and used to estimate the dose necessary to kill the regrowth of tumour cells which survived the first part of the split-course treatment. The estimated dose was 40 +/- 4 cGy per day of the rest interval. The doubling time was then calculated by means of schematic survival curves for fractionated irradiation. It was found that the tumor cells which survive the first part of the split-course treatment have the doubling times 3.5 +/- 0.5 days.
对52例采用连续照射或分段照射治疗的Ⅰ期和Ⅱ期喉癌患者进行了分析。两组患者的5年照射治愈率相同。绘制了治愈肿瘤的等效应线，并用于估计杀死在分段治疗第一部分后存活的肿瘤细胞再生长所需的剂量。估计的剂量为休息间隔期间每天40±4 cGy。然后通过分次照射的示意性生存曲线计算倍增时间。结果发现，在分段治疗第一部分后存活的肿瘤细胞的倍增时间为3.5±0.5天。
