[硝基呋喃衍生物对大鼠肝脏线粒体氧消耗的影响]
[Effect of nitrofuran derivatives on the oxygen consumption by rat liver mitochondria].
作者信息
Kozhanova S V, Basenova A T, Buzurbaev G G
出版信息
Vopr Med Khim. 1980 Sep-Oct;26(5):605-8.
PMID:7423873
Abstract
Utilization of oxygen in rat liver mitochondria was studied using two nitrofuran derivatives 5-nitro-2-furaldehyde semicarbazone (furacin) and soluble derivative of nitrofuran--M-106-P. The substances at 10(-3) M concentration increased O2 consumption in mitochondria with simultaneous decrease in the respiratory control. After blocking of respiration with KCN, antimycine, rhothenone, the nitrofurans stimulated O2 consumption in mitochondria up to 30% as compared with controls.
摘要
使用两种硝基呋喃衍生物5-硝基-2-糠醛半卡巴腙（呋喃西林）和硝基呋喃的可溶性衍生物M-106-P研究了大鼠肝脏线粒体中氧气的利用情况。浓度为10⁻³ M的这些物质增加了线粒体中的氧气消耗，同时呼吸控制能力下降。在用氰化钾、抗霉素、鱼藤酮阻断呼吸后，与对照组相比，硝基呋喃刺激线粒体中的氧气消耗增加了30%。
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