Savov V M, Kagan V E, Prilipko L L
Vopr Med Khim. 1980 Sep-Oct;26(5):623-7.
The peroxidative radicals arizing after destruction of exogenous hydroperoxides catalyzed by cytochrome P-450, carried out important functions in induction of lipid peroxidation, dependent on organic hydroperoxides. Only a slight inhibitory effect of singlet oxygen and anion radicals of superoxide on organic hydroperoxide dependent process of lipid peroxidation suggested that these active forms of oxygen participated apparently in lipid peroxidation. The traps of hydroxyl radicals (.OH) did not affect the lipid peroxidation induced by organic hydroperoxides. A mechanism is discussed for generation and function of peroxidative radicals as well as of active oxygen forms in lipid peroxidation, induced by organic hydroperoxides in liver microsomal membranes.
由细胞色素P - 450催化的外源性氢过氧化物破坏后产生的过氧化自由基，在依赖有机氢过氧化物的脂质过氧化诱导中发挥重要作用。单线态氧和超氧阴离子自由基对依赖有机氢过氧化物的脂质过氧化过程仅有轻微抑制作用，表明这些活性氧形式显然参与了脂质过氧化。羟基自由基（·OH）的捕获剂不影响有机氢过氧化物诱导的脂质过氧化。本文讨论了肝脏微粒体膜中由有机氢过氧化物诱导的脂质过氧化过程中过氧化自由基以及活性氧形式的产生和作用机制。
