Leithner C, Silberbauer K, Sinzinger H, Klein K, Stachelberger H, Stummvoll H K, Wolf A, Pinggera W
Wien Klin Wochenschr. 1980 Jun;92(13):476-80.
In haemodialysis an interaction between platelets and the dialysator membrane occurs, which is not prevented by heparin. This can be demonstrated by parietal depositions of platelets in the capillaries of the artificial kidney by scanning electron microscopy, as well as in a marked increase of reversible platelet microaggregates during the first phase of dialysis. Some patients are prone to develop thrombosis of the capillary kidneys in spite of a high-dose heparinization. In these cases the use of diclofenac, a cyclooxygenase inhibitor, prevents these adverse platelet reactions.
在血液透析过程中，血小板与透析器膜之间会发生相互作用，而肝素无法阻止这种相互作用。这可以通过扫描电子显微镜观察到人工肾毛细血管中血小板的壁沉积来证明，同时在透析第一阶段可逆性血小板微聚集体也会显著增加。尽管进行了大剂量肝素化，一些患者仍容易发生肾毛细血管血栓形成。在这些情况下，使用环氧化酶抑制剂双氯芬酸可预防这些不良的血小板反应。
