Szegedy L, Sótonyi P, Balogh I
Acta Morphol Acad Sci Hung. 1978;26(1):11-20.
The ultrastructure of the rat cerebellar cortex and the activity of succinic dehydrogenase were examined during methionine sulphoximine (MSO)-provoked convulsions. The animals were killed 3, 6 and 12 hours after the injection of 600 mg/kg of MSO. Convulsions appeared 4--5 hours, status epilepticus developed 8-9 hours after the injection. Progressive ischaemic changes of Purkinje cells could be observed, with condensation of the nucleus and a density of the cytoplasmic matrix. The cisternae of the Golgi complex and endoplasmic reticulum showed some degree of dilation. The basis of Purkinje cells was surrounded by distorted axons and terminals that had lost in most cases the synaptic vesicles, and by clear spaces due to the swollen glial processes. Three to six hours after MSO injection, succinic dehydrogenase activity increased in the mitochondria of Purkinje cells. After the appearance of seizures the enzyme activity decreased. Twelve hours after the injection the enzyme activity recovered to a certain extent.
在蛋氨酸亚砜亚胺（MSO）诱发惊厥期间，对大鼠小脑皮质的超微结构和琥珀酸脱氢酶活性进行了检查。在注射600mg/kg MSO后3、6和12小时处死动物。惊厥在注射后4-5小时出现，癫痫持续状态在注射后8-9小时发展。可观察到浦肯野细胞进行性缺血性改变，细胞核浓缩，细胞质基质密度增加。高尔基复合体和内质网的池显示出一定程度的扩张。浦肯野细胞的基部被扭曲的轴突和终末包围，这些轴突和终末在大多数情况下失去了突触小泡，并且由于神经胶质细胞突起肿胀而出现间隙。注射MSO后3至6小时，浦肯野细胞线粒体中的琥珀酸脱氢酶活性增加。癫痫发作出现后，酶活性降低。注射后12小时，酶活性在一定程度上恢复。
