Voronin L L
Acta Neurobiol Exp (Wars). 1980;40(1):335-70.
Spikes and postsynaptic potentials (PSPs) were recorded in the sensorimotor cortex of awake rabbits. (1) A cellular analog of cortico-cortical conditioned reflex (CR) was studied. Direct cortical stimulation of a remote point (conditional stimulus - CS) was paired with the stimulation near the microelectrode insertion (unconditional stimulus - UCS). The most neurons showed response facilitation when short intertrial intervals and strong UCS were used. These changes were short-lasting (up to 30 s) and were explained by posttetanic potentiation. Of 21 units tested with long (7 to 120 s) intertrial intervals, 9 showed significant response modification of longer duration. (2) The analog of cortico-cortical CR was modified using stimulation of homolateral cortex as the CS. The UCS was complimented by lateral hypothalamic reinforcement (LHR) in instrumental or classical paradigm. Of 37 units tested, 5 showed an increase in the probability of short-latency ( less than 25 ms) spike. (3) Extracellular activity of 17 neurons was followed through the entire cycle of elaboration and extinction of a "local conditioned startle response" established by pairing click CS with cortical UCS and LHR. Responses of 7 neurons showed significant modifications. The latency distributions of averaged PSPs were compared for naive (N), conditioned (C) and extinguished (E) states. Latencies in N and E groups were similar but were different from those in C group. Of 41 C group neurons, 26 responded at a latency of less than 17 ms; and 9 responded after less than or equal to 7 ms. A pathway for this simple CR may pass through the cortex. Thus PSP changes were observed in all models. Augmentation of short-latency EPSPs support the idea that an increase in efficacy of excitatory synapses underlies the conditioning. Interneuronal excitatory connections within the sensorimotor cortex are, presumably changed during elaboration of simplest motor CRs. These connections can be analyzed with intracellular recordings triggered by spikes of a neighbouring neuron.
在清醒家兔的感觉运动皮层记录了锋电位和突触后电位（PSP）。（1）研究了皮质 - 皮质条件反射（CR）的细胞类似物。对远处点进行直接皮层刺激（条件刺激 - CS）与微电极插入点附近的刺激（非条件刺激 - UCS）配对。当使用短的试验间隔和强的UCS时，大多数神经元表现出反应易化。这些变化是短暂的（长达30秒），并由强直后增强来解释。在21个采用长（7至120秒）试验间隔测试的单位中，9个表现出持续时间更长的显著反应改变。（2）使用同侧皮层刺激作为CS对皮质 - 皮质CR的类似物进行了修改。在工具性或经典范式中，UCS由外侧下丘脑强化（LHR）补充。在37个测试单位中，5个表现出短潜伏期（小于25毫秒）锋电位概率增加。（3）通过将点击CS与皮质UCS和LHR配对建立的“局部条件性惊吓反应”的整个形成和消退周期，跟踪了17个神经元的细胞外活动。7个神经元的反应表现出显著改变。比较了未处理（N）、条件化（C）和消退（E）状态下平均PSP的潜伏期分布。N组和E组的潜伏期相似，但与C组不同。在41个C组神经元中，26个在潜伏期小于17毫秒时做出反应；9个在小于或等于7毫秒后做出反应。这种简单CR的通路可能穿过皮层。因此，在所有模型中都观察到了PSP变化。短潜伏期兴奋性突触后电位的增强支持了兴奋性突触效能增加是条件化基础的观点。在最简单的运动CR形成过程中，感觉运动皮层内的中间神经元兴奋性连接可能发生了变化。这些连接可以通过相邻神经元锋电位触发的细胞内记录来分析。
