Nishioka N, Mikanagi K
Adv Exp Med Biol. 1980;122A:47-54. doi: 10.1007/978-1-4615-9140-5_8.
The clinical aspects of gout were described based on the 4,112 patients observed in the same clinic. In this paper mainly, 2,455 cases seen between 1958 and 1973 were described based on a pretrospective computer assisted analysis. The age distribution of the patient had its peak at 50 years of age and the average age at the time of onset was 49.5 years for males and 54.2 years for females. Recently, in Japan, the incident of gout among second and third decades has increased. The sex distribution, showed a predominance in males (99%). Primary gout in females before the neopause was very rare, only 0.08% of all subjects. Cases with a definite hereditary incidence comprised 7.5% and male sibling involvement was the most frequent. 68.4% of the patients had their initial gouty attack in the MTP joint of the great toe. 47.4% of the patients had a history of gouty attacks in two or more joints. Cases with tophaceous gout composed 9.2%, however, recently it has been decreasing in number every year.
基于在同一家诊所观察到的4112例患者描述了痛风的临床情况。本文主要基于一项回顾性计算机辅助分析，描述了1958年至1973年间所见的2455例病例。患者的年龄分布在50岁时达到峰值，男性发病时的平均年龄为49.5岁，女性为54.2岁。最近，在日本，二三十岁人群中痛风的发病率有所上升。性别分布显示男性占主导（99%）。绝经前女性的原发性痛风非常罕见，仅占所有受试者的0.08%。有明确遗传发病率的病例占7.5%，男性同胞受累最为常见。68.4%的患者首次痛风发作发生在大脚趾的跖趾关节。47.4%的患者有两个或更多关节痛风发作史。痛风石性痛风病例占9.2%，然而，近年来其数量每年都在减少。
