尿毒症血清对甲状旁腺激素（PTH）介导的、来自组织培养中的正常大鼠胚胎骨的钙释放的影响。
Effect of uremic sera on parathyroid hormone (PTH) mediated release of calcium from normal rat embryonal bone maintained in tissue culture.
作者信息
Letteri J M, Asad S, Olmer J
出版信息
Adv Exp Med Biol. 1980;128:635-43. doi: 10.1007/978-1-4615-9167-2_65.
PMID:7424693
Abstract
- 45Ca released from embryonal fetal rat bone into a tissue culture system containing uremic serum was lower than 45Ca measured in culture media containing normal sera. 2. With stimulation of bone calcium mobilization by the addition of PTH, 1,25(OH)2D3, 24,25(OH)2D3 and 25 (OH)2D3, the 45Ca released into media containing uremic serum was significantly lower than measured in cultures containing normal serum. 3. Addition of PTH in combination with 24,25(OH)2D3 or with 24,25(OH)2D3 and 1,25(OH)2D3 to bone cultures containing uremic serum increased the 45Ca released into the media when compared to cultures containing uremic serum and PTH.
摘要
- 从胚胎期大鼠胎儿骨骼释放到含有尿毒症血清的组织培养系统中的45Ca低于在含有正常血清的培养基中测得的45Ca。2. 通过添加甲状旁腺激素（PTH）、1,25-二羟维生素D3、24,25-二羟维生素D3和25-羟维生素D3刺激骨钙动员后，释放到含有尿毒症血清的培养基中的45Ca显著低于在含有正常血清的培养物中测得的45Ca。3. 与含有尿毒症血清和PTH的培养物相比，向含有尿毒症血清的骨培养物中添加PTH与24,25-二羟维生素D3或与24,25-二羟维生素D3和1,25-二羟维生素D3的组合可增加释放到培养基中的45Ca。
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