甲状腺激素导致的肝脏酒精代谢酶活性改变。

Alterations of hepatic alcohol metabolizing enzyme activities due to thyroid hormones.

作者信息

Moreno F, Minzlaff M, Hauptmeier K H, Teschke R

出版信息

Adv Exp Med Biol. 1980;132:109-15. doi: 10.1007/978-1-4757-1419-7_12.

Abstract

In order to achieve a hyperthyroid state, rats were treated for 7 days with thyroxine (150 microgram/100 g BW) or triiodothyronine (10 microgram/100 g BW). This regimen resulted in an enhanced activity of the microsomal ethanol oxidizing system. In addition, a decrease of hepatic alcohol dehydrogenase activity was observed under these experimental conditions, whereas hepatic catalase activity remained unchanged. These findings suggest that if chronic ethanol consumption simulates a functional "hyperthyroid hepatic state", increased rates of ethanol metabolism observed following prolonged alcohol intake might therefore be attributed at least in part to an induced activity of the microsomal ethanol oxidizing system in the liver.

摘要

为了达到甲状腺功能亢进状态，用甲状腺素（150微克/100克体重）或三碘甲状腺原氨酸（10微克/100克体重）对大鼠进行7天的治疗。这种方案导致微粒体乙醇氧化系统的活性增强。此外，在这些实验条件下观察到肝醇脱氢酶活性降低，而肝过氧化氢酶活性保持不变。这些发现表明，如果慢性乙醇摄入模拟一种功能性“甲状腺功能亢进性肝状态”，那么长期饮酒后观察到的乙醇代谢率增加可能至少部分归因于肝脏中微粒体乙醇氧化系统的诱导活性。