Walter S D
Am J Epidemiol. 1980 Sep;112(3):409-16. doi: 10.1093/oxfordjournals.aje.a113007.
This paper addresses the question of choosing between alternative preventive strategies for diseases with several risk factors. Estimates are obtained of the reduction in cases to be anticipated following a modification of the population exposure to one or several of these hazards. In practice, such estimates must often be made without knowledge of the joint distribution of exposure to risk, and so general conditions are established under which the factor attributable risks, calculated by ignoring all other factors, are unbiased effect measures. These concepts are illustrated by data from several epidemiologic studies.
本文探讨了针对具有多种风险因素的疾病在不同预防策略之间进行选择的问题。我们获得了在改变人群对一种或多种此类危险因素的暴露后预期病例数减少的估计值。在实际操作中，往往必须在不了解风险暴露联合分布的情况下做出此类估计，因此我们建立了一般条件，在这些条件下，通过忽略所有其他因素计算出的因素归因风险是无偏效应量度。这些概念通过多项流行病学研究的数据进行了说明。
